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Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary results of a 2-month prospective study

MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

Eye 33 , 206211 (2019)

The cyclic lactam structure that defines MT-II has served as a template for subsequent melanocortin-receptor probe development, including the receptor-selective antagonist series reported by Hruby and colleagues in 1995 using bulky aromatic substitutions at position 7 [8]

Figures shown are based on internal clinical data and do not constitute a promise or guarantee of specific results