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Anti-tumor necrosis factor treatment of interferon- -induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation

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Tolbutamide (a first-generation SU), glibenclamide (a second-generation SU), and glimepiride (sometimes classified as a third-generation SU), for instance, target the SUR-1 found in cells and, to a certain extent, the SURs 2A and 2B found in cardiac tissue and smooth muscle, respectively, while gliclazide MR (a third-generation SU) only has a high affinity for SUR-1 [19,20,21]