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FIGURE 8 FIGURE 9 In good agreement with this observation, a simple accumulation of Nrf2 is not sufficient for the development of spontaneous cancers (Taguchi et al., 2010), although a large number of human cancers depend on Nrf2 activity

Several studies have demonstrated the potential of probiotics in cancer prevention through various mechanisms including modification of microbiota, neutralization of carcinogens, vitamin and short-chain fatty acids synthesis, improved gut barrier function, inhibition of cell proliferation, cell apoptosis, and anti-inflammatory and anti-pathogenic activity with effects on lowering tumor growth and metastasis

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conversely, the diagnosis is frequently delayed in patients with NF1 due to potential misdiagnosis of these lesions as classical neurofibroma and/or plexiform neurofibroma [20]

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