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The interaction is so dangerous that the FDA has included a boxed warning, the most serious type of alert, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Other Drug Classes That Cause Drowsiness Any CNS depressant, listed in the above table, can be problematic when used with alprazolam, because they increase the risk of drowsiness, dizziness, being off-balance, and difficulty concentrating

Many of the dioxins and other halogenated aromatic hydrocarbons are hepatocarcinogenic in rats