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Together, current evidence indicates that addictive drugs induce stimulus- and region-specific dopaminylation of histone H3, shaping transcriptional programs involved in reward processing and drug-seeking behavior

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PMID: 9862719

Therefore, GLP-1RA may induce or exacerbate depressive phenotypes in some susceptible populations, while in others it may exert antidepressant effects by improving metabolism and inflammation

For instance, Europe is expected to grow significantly in the GLP-1 receptor agonist market during the forecast period, due to the growing diabetes burden