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These include variability in treatment response and, in the context of weight-loss indications, treatment plateaus and rebound weight gain

Obes Med 52: 100569

Moreover, the tumor microbiota is positively correlated with mitochondrial metabolic activity [87, 88], forming a microbiotametabolismimmunity axis that underpins a multidimensional resistance network and offers new insights for next-generation tumor microenvironmenttargeted strategies

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