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By performing microarray gene expression analysis in -cells isolated from 60-week-old mice, we found that MOTS-c downregulates genes related to mTOR pathway ( Cd38 , Camk2a , Map2k6 , Gck , and Ulk4 ) 71,93,94,95 and serine/threonine protein kinase ( Ripk1 , Styx , Wnk1 , Mapkapk3 and Ptk2b ), which regulates protein phosphorylation (Fig

4) Petrelintide (long-acting amylin analog): Two phase 2 trials are ongoing for people with overweight or obesity, one expected to complete in March 2026

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Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP