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[2] The Phase 3a REDEFINE 2 trial then tested once-weekly CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) against placebo in 1,206 adults with obesity and type 2 diabetes over 68 weeks, reporting a mean bodyweight change of 13.7% versus 3.4% for placebo

However, pricing transparency is a weakness: the true monthly cost of $299 is significantly higher than the advertised $149 first-month price, and post-discount pricing is buried in FAQs

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Many people lose between 0.5 and 2.5 pounds per week, which means losing 20 pounds may take approximately 8 to 20 weeks

Risk of thyroid C-cell tumors: Contraindicated in patients with relevant history