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While several epidemiological and clinical studies have explored the benefits of polyphenol consumption, limitations such as small sample sizes, lack of controls, varied methodologies, and heterogeneous data correlations have been observed

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Furthermore, growth factor-dependent pathways such as MAPK (extracellular signal-regulated kinases 1 and 2 [ERK 1/2]) and protein kinase B are found to be affected by GIP activation [20]