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However, some patients report experiencing cramps during treatment, potentially due to indirect factors like dehydration, electrolyte imbalances from gastrointestinal side effects, or nutritional changes associated with reduced appetite

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Strategies that help across all dose levels include eating smaller, more frequent meals rather than three large ones, avoiding fatty, greasy, or spicy foods which slow already-delayed gastric emptying, staying well hydrated throughout each day, taking your injection in the evening after dinner rather than morning, and not lying down immediately after eating

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Retatrutide has higher rates of nausea, diarrhea, and vomiting than tirzepatide