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Because there is not enough high-quality human evidence to support routine clinical use and they are not currently approved for use in Humans by Health Canada or the FDA
Analysis of single-cell sequencing datasets, along with immunohistochemistry and immunofluorescence staining validation, have revealed that abnormally activated lipid peroxidation in CD163+ macrophages and CD10 + PC+ (pyruvate carboxylase) epithelial cells suggests their potential involvement in ferroptosis within the glomerular compartment [132]
Filippatos T
doi: 10.1590/fst.02219
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