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22 After its formation, TMAO is excreted from the liver into the bloodstream via specialized transporters

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Starting at subtherapeutic doses (microdosing protocols) or using compounded formulations with customized titration steps may help patients build tolerance before advancing to standard maintenance doses

The glycolysis rate of WT-IR and L973F-IR preadipocytes was measured by Seahorse XFe96 Bioanalyzer (Agilent Technologies) according to the protocol of the Agilent Seahorse XF Glycolysis Stress Test Kit (14)