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Oocyte maturation interference independent of weight loss Preclinical studies suggest that glucagon-like peptide-1 receptor agonists may influence ovarian signaling, including granulosa cell pathways and intrafollicular growth factors such as IGF-1 and AMH, though direct human evidence is sparse [22]

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In line with these findings, a comprehensive network meta-analysis demonstrated that SGLT-2 inhibitors, GLP-1RAs, thiazolidinediones, and metformin were all associated with reduced dementia risk in DM2 patients, with SGLT-2 inhibitors and GLP-1RAs showing the strongest protective effects 89

But how do these drugs compare, and which one might be best for you