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Losing 20 kg of pure fat while maintaining all your muscle mass produces a dramatically different health outcome than losing 15 kg of fat and 5 kg of muscle

Slow, Structured Titration: Doses start low and increase gradually over weeks to minimize side effects

Starting elderly patients at 2.5 mg remains appropriate, but extending each dose tier to 6 to 8 weeks rather than 4 weeks improves tolerability

DEXA measures bone mineral density at the lumbar spine and hip, producing T-scores that classify bone health as normal (T-score above -1.0), osteopenic (T-score between -1.0 and -2.5), or osteoporotic (T-score below -2.5)

Shedding often resolves without discontinuing treatment