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Because a consistent dimension is essential for constant drug loading and targeted delivery, this size variance affects downstream usage, particularly when employing EXOs as pharmaceutical delivery carriers (Han et al., 2022)

In human anecdotal reports, the most commonly cited side effects include: Mild nausea (especially with oral dosing on an empty stomach) Lightheadedness or dizziness Headache Slight fatigue in the first few days Injection site irritation (minor pip, if injectable) Honestly, most people report zero sides

However, HeLa cells are much more sensitive, with 2.5 nM (per million cells) of doxorubicin resulting in up to 80% GSH depletion for the same exposure time 38