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Principles and functions of metabolic compartmentalization

Conclusions After adjusting for clinical, demographic, biochemical, and pharmacological confounders the combined assessment of transsulfuration pathway thiols shows that glutamylcysteine has the strongest and positive independent associations with ADMA and SDMA

c , Compartment of IC50 between A01, A17, SMART1Et and SMART1 (72 h) in HCT116 cells (n = 4 independent experiments)

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Their analysis predicted that subjects with elevated HS have an altered demand for GSH and NAD +