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Additionally, contrarily to rodents, its effect in humans does not appear to be mediated by FGF21 [45]

Move but dont go overboard

Expression of these thyroid antigens in the fetal thymus is under control of the AIRE gene, and absence of this gene leads to polyglandular autoimmune syndrome type 1 whose hallmarks are adrenal insufficiency, hypoparathyroidism and muco-candidiasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Terrill SJ, Jackson CM, Greene HE, Lilly N, Maske CB, Vallejo S, et al

While the amount of weight lost is a primary factor, age, skin elasticity, and the speed of weight loss also play a role