FDA-approved drugs in each class GLP-1 receptor agonist medications include semaglutide (Ozempic, Wegovy, Rybelsus), tirzepatide (Mounjaro, Zepbound also a GIP agonist), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and exenatide (Byetta, Bydureon)
The American Diabetes Association Standards of Care recommend GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who have established cardiovascular disease or indicators of high cardiovascular risk, or when weight loss is a priority
Social withdrawal dropped by 31%[2]
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A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation