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Finally, we validated public sentiment and policy rigor

When insulin sensitivity drops: GLP-1 signaling becomes less effective The body may produce less GLP-1 Tissues respond less to the GLP-1 that is available This creates a metabolic feedback loop that can worsen blood sugar control over time

Causes: Vitamin B12 deficiency, nerve compression (sciatica, herniated disc), multiple sclerosis, peripheral neuropathy

FIGURE 2 4.3 Stimulation of cell proliferation and induction of islet neogenesis The proliferation potential of pancreatic cells is very limited

When you stop taking a GLP-1 drug, some of the effects you experienced while on the medication may reverse: Increased appetite and cravings: Without the appetite-suppressing effects of the medication, many people notice a return of hunger and stronger food cravings