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Phase III studies enrolled more than 1,400 patients and demonstrated that exenatide effectively lowered blood glucose while producing an unexpected but welcome side effect: weight loss

Plasma MOTS-c itself is not yet widely available as a clinical laboratory test, though research assays exist

Clinical data show reductions in liver fat and improvements in metabolic markers

Losing muscle is not

3.6 Potential Microbiome Changes GLP-1 receptor agonists alter: Gastric motility Transit time Food intake patterns Emerging research suggests that weight loss and altered dietary intake may influence gut microbiota composition. At present, there is insufficient evidence to conclude that GLP-1 drugs independently cause clinically significant microbiome-mediated nutrient depletion