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This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses
792 Amino acid metabolism Excessive glutamine uptake by cancer cells results in a shortage of glutamine in the TME, tipping the immune balance toward suppression
Accordingly, evidence is graded in this report as: Level A (highest) : authorised product information and pivotal trial safety tables as reported in labelling (high internal validity