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Heavy pollution exposure, smoking, poor sleep and a diet low in protein variety are useful clues in the meantime

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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

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177 The results of this oral intake were not only negative but also inconclusive, which would be expected due to the lack of the modern-day understanding that proteins are proteolytically degraded in the stomach