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Avoid using GLP-1 RAs if you have a personal or family history of medullary thyroid carcinoma or MEN2 syndrome (Multiple endocrine neoplasia type 2 syndrome)

Gradual dose escalation can help minimize GI symptoms like nausea or abdominal pain

Its estimated primary completion is December 2026, so no final head-to-head result is available yet

A 2022 trial indicated that GLP-1 receptor activation can influence dopamine pathways, potentially lowering alcohol reward behaviour

All such tumors share an architectural growth pattern that simulates vertical growth phase melanoma but lack the cytologic features diagnostic of malignant transformation