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Adams JD Jr, Klaidman LK, Odunze IN, Shen HC, Miller CA (1991)
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Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)
Glutathione is often called the"Master Antioxidant" because it plays a key role in protecting cells from oxidative stress and supporting natural detoxification processes
Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M
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