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Endocr Rev

Several CoQ biosynthesis genes have been implicated in epilepsy including COQ1-PDSS2 , COQ2 , COQ4 , COQ5 , COQ6 , COQ8-ADCK3 , COQ8-ADCK4 , and COQ9 , with COQ2 , COQ4 , and COQ8-ADCK3 mutations being more frequently associated with seizures (124)

But frequency cannot always make up for a poor delivery method

Clinicians often turn to rifabutin when standard antibiotics like doxycycline or rifampin have failed, particularly in chronic or treatment-resistant Lyme presentations