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Additionally, -Ketoglutarate(-KG) inhibited ferroptosis, significantly reducing matrix degradation and apoptosis in chondrocytes via the ETV4/SLC7A11/GPX4 signaling pathway, showing future clinical application prospects ( in vivo metabolism

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Beyond DIOs, genetic variants in SelPs (e.g., rs3877899 and rs7579) affect Se transport efficiency and the distribution of Se to target tissues like the thyroid