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An association was also found between abnormal small intestinal permeability and a specific mutation in the NOD2 gene, which functions to modulate immune responses to intestinal bacteria, suggesting a genetic pathway in which an abnormal intestinal barrier could lead to chronic intestinal inflammation [85,86]

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The Micro-Infusion System for Dark Spots and for Wrinkles underwent an independent clinical evaluation of dermatologic safety-in-use conducted by a Board-Certified Dermatologist