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[21] A randomized, double-blind, placebo-controlled study on oral glutathione supplementation (500 mg twice daily for four weeks) in 40 healthy adult volunteers failed to show any significant change in serum glutathione levels

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It is reported that the level of the protein-bound form of glutathione increases 12 h after ingestion of glutathione, which suggests that orally administered glutathione is absorbed into the blood [12]