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Glucagon Like Peptide 1 (GLP-1) mimetic drugs which mimick the action of native GLP-1 as an incretin hormone have become a common second line of therapy for Type 2 diabetes (61, 80)

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Among them RSL3 and ML162 were first described as direct inhibitors of GPX4, while others such as erastin and sulfasazaline were shown to target the Xc- transport system (Fig