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The test screens for key variants such as GLP1R rs6923761 and analyzes 14 distinct metabolic pathways and 49 peptides across 150+ genetic insights
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Exenatide infusion decreases atrial natriuretic peptide levels by reducing cardiac filling pressures in type 2 diabetes patients with decompensated congestive heart failure
For the GLP-1R V229A, however, we observed a higher proportion of receptors pre-existing as higher order oligomers under vehicle conditions, with no further increases after exendin-4 stimulation, indicating that the mutant receptor has a higher clustering propensity in the inactive state
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