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24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism

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