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The mechanism is partly through inhibiting the expression and activity of matrix metalloproteinase-9 (MMP-9) ( in vivo , promote its BBB permeability and neuron targeting, and significantly increase the content of miR-124 in hippocampus of APP/PS1 mice, which has good therapeutic effect in vivo

Radiotherapy resistance (RR) can occur due to multiple factors, including genetic mutations, altered DNA repair mechanisms, and changes in the tumor microenvironment (59)

Furthermore, FTO knockdown suppressed the activation of TNF--induced cGAS-STING signaling, accompanied by the decreased expression of inflammatory cytokines such as IL-6 and IL-18, subsequently alleviating AIA (61)

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The choice of medication should be made carefully, considering individual factors such as body weight, BMI, and blood sugar levels