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The ends of bones are covered with a cushion of articular cartilage, a slippery tissue that helps the bones glide easily across each other during movement

These effects are often dose-related and may lessen as the body adjusts to the medication

Across large RCTs and meta-analyses, these medications consistently reduce hospitalization for HF across the ejection fraction spectrum, with reductions in cardiovascular death and all-cause mortality most firmly established in HFrEF (and in chronic kidney disease and atherosclerotic disease) [6, 14, 41, 42]

Postural Orthostatic Tachycardia Syndrome (POTS)A novel member of the autoimmune family

Poorly controlled diabetes increases the fetal risk for major birth defects, stillbirth, and macrosomia-related morbidity