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This is where the concept of bioavailability becomes critical

MDPI Hsieh MJ et al

Bifidobacteria are early colonisers of the infant gut and produce SCFAs, like acetate and lactate, which cross-feed other gut inhabitants, including butyrate producers, such as Faecalibacterium prausnitzii

Between mid-2024 and early 2025, monthly US searches for "GLP-1 patches" surged from near zero to over 57,000, driven entirely by consumer interest in cheaper, easier alternatives to GLP-1 injections

The resultant opening of voltage-dependent L-type Ca 2+ channels increases the intracellular concentration of Ca 2+ , which also acts as a second messenger, augmenting neurotransmitter release [33]