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1 The International Diabetes Federation (IDF) has listed approximately 537 million adults with diabetes in 2021, a number expected to increase to 643 million by 2030

If gastrointestinal side effects are severe or persistent despite conservative measures, dose reduction or medication discontinuation should be considered in consultation with the prescribing physician

There are also signs of improvement in some markers of insulin resistance and, to a lesser extent, in body weight, although this latter effect is more inconsistent and less robust

There are chronic inflammatory changes and macrophages