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Lifestyle and Nutrition Diet: Diets that are high in protein and consist of a high intake of energy are associated with higher IGF-1 levels 53 , while fasting, low-calorie, and ketogenic diets are associated with lower IGF-1 levels 54

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This distinction matters because the FDA has issued repeated safety communications about compounded hormone therapy products (FDA bioidentical hormone therapy communication), noting that custom-compounded products lack the safety and efficacy data of FDA-approved agents

Molloy JW, Calcagno CJ, Williams CD, Jones FJ, Torres DM, Harrison SA (2012)