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The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier

[DOI] [PubMed] [Google Scholar] 9.Hemil H, Chalker E

And it may be the most important one

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P -values adjusted for multiple testing for both continuous and categorical analyses should be 0.05