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Deletion of the transcription factor, nuclear factor erythroid 2-related factor 2 (NRF2), in the livers of mice blunted but did not abolish the increase in PSAT1 mRNA (16)

Metformin works by decreasing the amount of glucose your liver produces

Consult your physician or healthcare practitioner if you have specific questions before instituting any changes in your daily lifestyle including changes in diet, exercise, and supplement use

doi: 10.1056/NEJMoa1607141 9 ArodaVR

When used as a behavioural reset - a period during which reduced appetite creates genuine space to adopt new eating patterns - short-term treatment can provide lasting benefit