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Do not use Semaglutide if: 1

Conversely, people who already present with high anhedonia, for instance, in the context of a depressive illness, may see their symptoms worsening when on GLP-1RAswhich could elucidate some of the studies reporting negative effects associated with these medications in mood and anxiety disorders

(2021) Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes, New England Journal of Medicine , 385, pp.503515

Front Endocrinol (Lausanne) (2021) 12:609470

Preparing for injection: Before administering your GLP-1 medication, allow the pen to reach room temperature if it has been refrigeratedthis reduces injection discomfort