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Collectively, the data from 20 healthy nonobese subjects indicated that elevated colonic propionate production diminished striatal blood oxygen level-dependent signals, especially in reaction to high-energy foods, indicating that propionate mitigates reward-driven eating behavior through striatal pathways, irrespective of alterations in plasma PYY, GLP-1, glucose, or insulin levels

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Older adults may respond differently to therapy and may need closer monitoring, particularly if they have other endocrine, metabolic, or cardiovascular conditions

8 (1), e12268

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