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The adverse events associated with GLP-1RA are predominantly GI, particularly nausea, vomiting, and diarrhea, and occur in 1050% of patients in clinical trials (Table 2) (94)

This is the smallest adjustment you can make and carries virtually no additional risk

With human analogs (liraglutide, semaglutide), the rates of anti-drug antibodies are much lower (around 58%) and high titers are rare

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