Overview of Clinical Trial Study 1 (NCT03574597) was a multi-national, multi-center, placebo-controlled, double-blind trial to determine the effect of WEGOVY injection relative to placebo on major adverse CV events (MACE) when added to current standard of care, which included management of CV risk factors and individualized healthy lifestyle counseling (including diet and physical activity) in adults with established CV disease and either obesity or overweight
Effect of WEGOVY Injection on Anthropometry and Cardiometabolic Parameters in Adults Changes in waist circumference and cardiometabolic parameters with WEGOVY injection are shown in Table 13 for Studies 2, 3, and 4
According to the Ozempic SmPC, injectable semaglutide does not significantly affect the exposure of combined oral contraceptives
Important safety considerations include boxed warnings for thyroid C-cell tumors (based on animal studies), and cautions regarding pancreatitis and gallbladder disease
Common side effects include: Nausea Diarrhea Vomiting Constipation Stomach pain These side effects usually improve over time as your body gets used to the medication