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Bret: I really admire your passion and appreciate your passion and your enthusiasm, and your approach from a research standpoint, and for all you do from an advocacy standpoint, and all you do to help the field of psychiatry move forward with a message of hope, like you just said

Plasma FABP1 levels are significantly elevated in AD patients and are positively correlated with cerebrospinal fluid (CSF) total tau and phosphorylated tau

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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population