Researchers note that further studies would help more definitively determine overall safety for breastfeeding patients and their babies, which aligns with the overall consensus over semaglutide and other glucagon-like peptide-1 (GLP-1) receptor agonists, which are not currently advised for use during pregnancy or while nursing
The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]
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