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doi: 10.1016/j.diabres.2021.108737

For patients with prediabetes or insulin resistance driving weight gain and metabolic dysfunction, semaglutide addresses the glycemic component while producing weight loss that further improves insulin sensitivity a compounding metabolic benefit

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The Summary of Product Characteristics (SmPC) for tirzepatide does not list L-carnitine as a substance that interacts with the medication, and there are no documented pharmacokinetic or pharmacodynamic interactions between these two agents in the current medical literature