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Meanwhile, Activation of AMPK further results in decrease of malonyl-CoA levels via inactivation of ACC, which effectively promotes fatty acid oxidation by relieving CPT-1 suppression ( Figure 1 )

After the translation of IGF - IR mRNA, the 210 kDa protein product (pro-IGF-IR) is subject to endoproteolytic cleavage by the pro-protein convertases such as furin and pro-protein convertase 5, leading to the generation of chain (706 amino acids) and chain (627 amino acids) [22]

Each tube was then added with 49 l of MSTFA (N-methyl-N-(trimethylsilyl)-trifluoroacetamide) and again incubated at 37C for 10 minutes at 900 g

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