p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
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Epithelium/endothelium protection might be easily achieved and further extended to the general level (protection of other organs) (cytoprotection to organoprotection) [3,4,32,33,34]
To explain this finding, it may be noted that GltT, although required for L-glutamate transport, is highly homologous to the VacJ/Yrb ABC transport system, a proposed phospholipid transporter for maintaining lipid asymmetry in the Gram-negative outer membrane (Mla pathway) (Malinverni and Silhavy, 2009), also involved in outer membrane vesicle (OMV) formation (Roier et al., 2016)
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