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Taken together, these results suggested that sitagliptin may also play a role of ROS scavenger and sitagliptin can prevent the activation of NFB signaling, which is also affected by the decreased ROS level to some extent

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In a follow-up analysis of data obtained from Q-SYMBIO clinical trials (Mortensen et al., 2014), Alehagen and colleagues were able to show that in elderly healthy participants who received selenium and CoQ 10 supplementation for over 4 years, an increase in insulin-like growth factor 1 (IGF-1) and postprandial insulin-like growth factor-binding protein 1 (IGFBP-1) levels, and greater age-corrected IGF-1 score based on the standard deviation of the mean value were observed compared with placebo-treated individuals (Alehagen et al., 2017)