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Published: July 26, 2023 Copyright: 2023 Baskerville et al

Brain DHA content may be particularly important, since animal studies have shown that depletion of DHA in the brain can result in learning deficits

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However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention