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578 Pharmacological treatments include cholinergic agonists, such as bethanechol, to stimulate detrusor muscle contraction, antimuscarinic agents, such as oxybutynin or tolterodine, for overactive bladder symptoms, and beta-3 agonists, such as mirabegron, to relax bladder smooth muscle during the storage phase

Under most conditions this may be the most important short-term regulatory signal, although it is, of course, possible that other regulatory effects play a role as well

This process happens gradually as your skin cells regenerate, typically taking several weeks to show visible results

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